女，生于1988年1月，吉林通化人，博士，助理研究员。
联系方式
Email: baiy@iae.ac.cn
研究方向
特境微生物次级代谢产物及其活性研究。
教育及工作经历
2007年9月-2011年7月 河北医科大学 药学 本科
2011年9月-2014年7月 沈阳药科大学 天然药物化学 硕士
2014年9月-2017年7月 沈阳药科大学 药物分析学 博士
2017年7月-2017年12月 四川科伦药物研究院 分析研究员
2018年4月-至今 中科院沈阳应用生态研究所 助理研究员
发表论文
- Yan Bai, Xiaodong Ma, Duo Ren, Guoqing Yu, Jiangchun Hu, Huiming Hua, Huaqi Pan*. Peniapyrones A-I,Cytotoxic Tricyclic-Fused α-Pyrone Derivatives from an Endophytic Penicillium brefeldianum F4a. J Nat Prod. 2024, 87(6):1643-1651.
- Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu, and Huaqi Pan*. Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Arabian Journal of Chemistry, 2024, 17, 105388.
- Yan Bai, Duo Ren, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Genome mining and molecular networking guided isolation of antimycin analogues with antifeedant activities from the deep-sea-derived Streptomyces sp. NA13. Chemistry & Biodiversity, 2023, 20, e202300715.
- Yan Bai, Ping Yi, Fenglin Li, Jiangchun Hu, Huaqi Pan*. Penipentenone A and brefeldin A derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a. Phytochemistry, 2022, 200: 113243.
- Xueying Xie, Zexi Zhao, Hetong Yang, Huaqi Pan, Changxiang Zhu, Jiangchun Hu, Yan Bai*. Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2. The Journal of Antibiotics, 2022, 75 (2), 117-121.
- Yan Bai, Ping Yi, Songya Zhang, Jiangchun Hu, Huaqi Pan*. Novel antioxidants and -glycosidase and protein tyrosine phosphatase 1B inhibitors from an endophytic fungus Penicillium brefeldianum F4a. Journal of Fungi, 2021, 7, 913.
- Yan Bai, Ping Yi, Yun Zhang, Jiangchun Hu, Ying Wang, Jianhua Ju, Huaqi Pan*. Structure-based molecular networking for the target discovery of novel germicidin derivatives from the sponge-associated streptomyces sp. 18A01. The Journal of Antibiotics, 2021, 74 (11), 799-806. (Highlighted article)
- Yan Bai, Qili Zhang, Baoyu Wang, Meiyan Zhang, Yan Xu, Shasha Li, Yunli Zhao*, Zhiguo Yu*. Plasma pharmacokinetics, bioavailability, and tissue distribution of four C-glycosyl flavones from mung bean (Vigna radiata L.) seed extracts in rat by ultrahigh-performance liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 2017, 65 (27): 5570-5580.
- Yan Bai, Yan Xu, Baoyu Wang, Shasha Li, Feng Guo, Huiming Hua, Yunli Zhao*, Zhiguo Yu*. Comparison of phenolic compounds, antioxidant and antidiabetic activities between selected edible beans and their different growth periods leaves. Journal of Functional Foods, 2017, 35: 694-702.
- Yan Bai, Jiawei Chang, Yan Xu, Dan Cheng, Hongxin Liu, Yunli Zhao, Zhiguo Yu*. Antioxidant and myocardial preservation activities of natural phytochemicals from mung bean (Vigna radiata L.) seeds. Journal of Agricultural and Food Chemistry, 2016, 64 (22): 4648-4655.
- Yan Bai, Yan Xu, Jiawei Chang, Xiaoxue Wang, Yunli Zhao, Zhiguo Yu*. Bioactives from stems and leaves of mung beans (Vigna radiata L.). Journal of Functional Foods, 2016, 25: 314-322.
- Yan Bai, Dahong Li, Tingting Zhou, Ningbo Qin, Zhanlin Li, Zhiguo Yu*, Huiming Hua*. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. Journal of Functional Foods, 2016, 20: 453-462.
- Xiaoying Zhang, Chunfeng Song, Yan Bai, Jiangchun Hu, Huaqi Pan*. Cytotoxic and antimicrobial activities of secondary metabolites isolated from the deep？sea？derived Actinoalloteichus cyanogriseus 12A22. 3 Biotech, 2021, 11: 283.
- 刘晶莹, 白岩, 潘华奇, 胡江春. 卡伍尔氏链霉菌NA4的 型聚酮基因簇的靶向激活及其产物鉴定. 微生物学报, 2023, 63 (10): 3891-3904.
- 石逸冰, 白岩, 潘华奇, 胡江春. 植物内生真菌F4a次级代谢产物的分离鉴定以及降血糖、抗氧化活性的研究. 微生物学杂志, 2022, 42 (2): 26-31.
